No prep + no time off = no reason not to screen
Backed by a decade of proven success, the Cologuard Plus® test pairs next-generation performance with the convenience of a use-at-home test.
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For adults 45+ at average risk for colon cancer -
Looks for both abnormal DNA and blood in the stool
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Negative results showed a 99.9% accuracy1*
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FDA-approved
The Cologuard Plus test detects 95% of colon cancers.1
This cancer detection rate is comparable to colonoscopy, based on a separate study.2†‡
Advanced detection, proven performance
Your colon naturally sheds cells with every bowel movement. Powered by 5 optimized biomarkers, the Cologuard Plus test scans those cells for abnormal DNA and blood to detect cancer and precancers.1
Also, in a subgroup of 20 adults ages 45–59, it was found that the Cologuard Plus test detected 100% of colon cancers.1
Get true peace of mind with a 99.9% performance rate for negative results1*— all from a simple use-at-home test that catches far more precancer than a standard FIT test.1§
Why it’s important to screen at 45
A new study by the American Cancer Society revealed why early detection matters:
- Colon cancer is now the #1 cause of cancer-related deaths among adults under 503
- 3 out of 4 patients under 50 are diagnosed with advanced colon cancer4
- It’s the only type where its mortality rate has increased since 2005, compared to the 4 other leading causes of cancer death3
No symptoms does not mean no risk
Colon cancer is one of the most preventable kinds of cancer. When caught in its early stages, it’s survivable in about 90% of people.5**
Still, the myth that you only need to get screened if you already have symptoms persists.
The truth is, early-stage colon cancer is often a silent disease without any warning signs.6 Waiting for symptoms often means the cancer has already progressed.
Screening made simple
No downtime, no prep – no changes to your diet or medications either.
Request a test
Either from your doctor or through our telehealth services, and a kit will be delivered to your home.
Receive your kit
Follow the included instructions, and collect a stool sample in your own space, at your own pace.
Ship back for results
Pack your sample, ship it back in the prepaid box, and get your test results in 8-10 days.
Screened with the Cologuard test
Read her storyHow the Cologuard Plus test compares
high-risk patients An ACS-preferred
noninvasive method Alternative
| Colonoscopy Visual exam |
Stool DNA test
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Blood tests
like
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FIT Fecal Immunochemical Test | FOBT Fecal Occult Blood Test | |
|---|---|---|---|---|---|
| Indicated for colon cancer detection1,8,9,10 |
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 ¶
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¶
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| Indicated for detection of precancer1,8,9,10 |
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#
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¶
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¶
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| Noninvasive |
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| No prep required |
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†
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| Collect sample at home |
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§§
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This table is not a complete list of all available colon cancer screening methods. ACS preferred options include stool-based tests (FIT/FOBT, stool DNA, stool RNA) and visual exams (colonoscopy, CT colonography, flexible sigmoidoscopy). A positive noninvasive test result requires a follow-up colonoscopy.
¶Indicated for the detection of fecal occult blood9
#Based on data from clinical studies, SimpleScreen CRC has limited detection of Stage I (57%) colorectal cancer (64% when U.S. 2020 Census age-sex adjusted) and does not detect 87% of advanced precancerous lesions (86% when U.S. 2020 Census age-sex adjusted). One out of 10 patients with a negative SimpleScreen CRC result may have a precancer that would have been detected by a screening colonoscopy.10
†FOBT requires changes to diet or medication8
§§Mobile phlebotomy may be available to collect a blood-based test sample at home with assistance from a medical professional10
Most insured people pay $0††
Cologuard is covered for people who are at average risk for colon cancer by Medicare and many major insurers. It only takes a moment to confirm if your insurance is in-network.
A limited number of patients may receive the original Cologuard test, which detects 92% of colon cancers.2
Ready to get started?
We can help you request a Cologuard Plus test today, either from your doctor or through a telehealth specialist.
Looking for a different way to screen?
The Cologuard Plus test is a preferred noninvasive colon cancer screening method by the American Cancer Society.12 If you’d rather take a blood test, head to our SimpleScreen CRC page to learn more.
Frequently asked questions
Cologuard Plus is the next-generation, FDA-approved version of Cologuard®, designed to detect colon cancer and precancer. Based on a subset of 18,911 average risk patients aged 45-84 years from a prospective, multicenter study, the Cologuard Plus test offers:
- Accurate detection: finds 95% of colon cancers
- Finds pre-cancers: detects 43% of advanced precancerous growths and 74% of high-risk lesions
- Peace of mind: a negative result means there's a 99.98% chance you don’t have colon cancer
Cologuard Plus uses advanced stool technology to detect blood and the DNA cells released from altered cells. It can detect both colon cancer and precancer.
Cologuard Plus detects blood and the DNA cells released from altered cells, and can detect both colon cancer and precancer.
If you’re 45+ and at average risk for colon cancer, there are two easy ways to request Cologuard Plus: online or through your health care provider. Either way, we’ll deliver your prescribed kit right to your door.
Your kit comes with easy-to-follow, step-by-step sample-collection instructions. You can also download our patient guide or watch our how-to videos.