Screen with the leading noninvasive colon cancer test in the privacy of your home1
- FDA approved
- No prep, no time off
- Collect a sample in a few minutes2
- Most people pay $0*
WHY EARLY DETECTION IS IMPORTANT
There’s no such thing as low risk for colon cancer
30%
of cases are increasingly shifting younger; 1 in 5, or 30% of new diagnoses, are in people under 55.2
75%
of people with colon cancer
have no family history.3
1st
Colorectal cancer is now the leading cause of cancer deaths in people under 50.4
HOW MUCH DOES THE COLOGUARD® TEST COST?
Most insured patients pay $0*
Our goal is to keep Cologuard® accessible to as many patients as possible. See whether your insurance is in-network now.
Insurance provider not found
Sorry, but your insurance may be out of network. Please call 1-866-267-2322 (Billing Enterprise) for assistance.
WHY THE COLOGUARD PLUS TEST
A leading noninvasive solution1
Made for individuals 45+ at average risk, the Cologuard Plus test stands out for its ease of use and proven effectiveness. Collect a sample in a few minutes.5
| Screening test feature |  |
Colonoscopy | FIT Fecal Immunochemical Test |
FOBT Fecal Occult Blood Test |
Blood test |
|---|---|---|---|---|---|
| Noninvasive |  |
 |
|
|
|
| No prep required | |
|
|
† |
|
| Collect sample at home | |
|
|
|
§§ |
| Indicated for colorectal cancer detection6,7 | |
|
¶ |
¶ |
|
| Indicated for detection of precancer6-9 | |
|
¶ |
¶ |
# |
Any noninvasive test with a positive result will need a follow-up colonoscopy.
†FOBT requires changes to diet or medication10
¶Indicated for the detection of fecal occult blood11
§§Mobile phlebotomy may be available to collect a blood-based test sample at home with assistance from a medical professional12
#Current FDA-approved CRC blood test does not detect 87% of precancerous lesions9
THE STORY BEHIND THE TEST
Backed by science, powered by technology13,14
Cologuard Plus helps find colon cancer in its early stages, when it is more treatable.
Gathering cells to uncover your body’s natural clues
- Polyps are small, usually harmless growths in the colon
- Left undetected, they can develop into cancer over time
- These polyps can shed cells or leave behind microscopic amounts of blood in the stool that become clues to detecting cancer
Advanced technology for targeted analysis
- Using exclusive technology, your stool sample goes through a purification process in our lab
- Cologuard Plus uses a precise biomarker panel to detect 4 distinct DNA markers (signs of DNA damage) and tiny blood traces, focusing on key mutations linked to colon cancer
- This multi-marker approach can detect cancer early, even before symptoms appear or become serious
Clear and actionable results within 8 to 10 days
- Abnormal DNA or blood findings are weighted for a more accurate prediction of your risk for colon cancer
- A positive result may mean a higher-than-average risk of precancerous polyps or colon cancer, while a negative result suggests a lower-than-average risk
AN FDA-APPROVED CHOICE
Trusted by over 340,000 providers.15 Chosen by 20 million patients.16
You’ve got questions,
we’ve got answers
Cologuard Plus is for adults 45 years of age and older who are at average risk for colon cancer. It is not a replacement for colonoscopy in high-risk individuals.
Cologuard Plus uses advanced stool technology to detect DNA and blood cells released from altered cells. It can detect both colon cancer and precancer.
In a study that included a subset of nearly 19,000 average-risk patients aged 45-86, Cologuard Plus detected 95% of Stage I to IV colon cancers. In a subset of 20 adults aged 45-59, Cologuard Plus detected 100% of all colon cancers.1
- Cologuard Plus® Clinician Brochure. Madison, WI: Exact Sciences Corporation.
If you’re 45+ and at average risk for colon cancer, there are two easy ways to request Cologuard Plus: online or through your health care provider. Either way, we’ll deliver your prescribed kit right to your door.
Cologuard Plus is the next-generation, FDA-approved version of Cologuard, designed to detect both colon cancer and precancer. Based on a subset of 18,911 average-risk patients aged 45-86 years from a prospective, multicenter study, the Cologuard Plus test offers1:
- Accurate detection: Finds 95% of colon cancers
- Finds precancers: Detects 43% of advanced precancerous growths and 74% of high-risk lesions
- Peace of mind: A negative result means there's a 99.98% chance you don’t have colon cancer
- Cologuard Plus® Clinician Brochure. Exact Sciences Corporation. Madison, WI.
The Cologuard Plus test detects blood and the DNA cells released from altered cells. It can detect both colon cancer and precancer.
Yes the Cologuard Plus test is FDA-approved to detect colon cancer and precancer.
Your kit comes with easy-to-follow, step-by-step sample-collection instructions. You can also download our Patient Guide or watch our how-to videos.
One of the most common myths and misconceptions is that you only need a screening if you’re experiencing symptoms like pain or bleeding. In reality, early-stage colon cancer is often a silent disease with no warning signs at all.1
The goal of screening is to find precancerous polyps before they turn into something serious, or to catch cancer when it’s small and highly treatable. Waiting for symptoms often means the disease has already progressed.
- CDC. Reducing Risk for Colorectal Cancer. Updated February 26, 2025. Accessed September 2, 2025. https://www.cdc.gov/colorectal-cancer/prevention/
In a study that included nearly 19,000 average-risk patients aged 45-86, Cologuard Plus detected 95% of Stage I to IV colon cancers. In a subset of 20 adults aged 45-59, Cologuard Plus detected 100% of all colon cancers.1
- Cologuard Plus® Clinician Brochure. Madison, WI: Exact Sciences Corporation.
The Cologuard Plus test is included on a wide range of insurance plans for eligible patients. Coverage can vary, check your insurance and which test is covered today.
To check if it’s available under your plan, use our insurance lookup tool.
Don’t strike out on screening
Watch how Albert Pujols and Cal Raleigh are teaming up with Cologuard Plus®