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Start screening in 15 minutes or less for your colon health — that's the GOOOOAL

  • The leading noninvasive test1
  • Use at home, no prep, no time off
  • FDA-approved
  • Most insured people pay $0*
THE COLOGUARD PLUS BOX HOLDS A SOCCER BALL ON A SOCCER FIELD.
THE COLOGUARD PLUS BOX HOLDS A SOCCER BALL ON A SOCCER FIELD.

WHY EARLY DETECTION IS IMPORTANT

There’s no such thing as low risk for colon cancer

30%

of cases are increasingly shifting younger; 1 in 5, or 30% of new diagnoses, are in people under 55.2

75%

of people with colon cancer
have no family history.3

1st

Colorectal cancer is now the leading cause of cancer deaths in people under 50.4

The Cologuard mascot standing with his hands on his hips.

HOW MUCH DOES THE COLOGUARD® TEST COST?

Most insured patients pay $0*

Our goal is to keep Cologuard® accessible to as many patients as possible. See whether your insurance is in-network now.

Provider Not Found

Congrats!
Iowa Medicaid plan is in network for Cologuard Plus.
Congrats!
Bcbs Iowa Wellmark Msa Medicare Advantage is in network for the Cologuard test.

WHY THE COLOGUARD PLUS TEST

A leading noninvasive solution1

Made for individuals 45+ at average risk, the Cologuard Plus test stands out for its ease of use and proven effectiveness. Collect a sample in a few minutes.5

Screening test feature Cologuard by Exact Sciences logo Colonoscopy FIT
Fecal Immunochemical Test
FOBT
Fecal Occult Blood Test
Blood test
Noninvasive yes no yes yes yes
No prep required yes no yes no§ yes
Self-collect at home yes no yes yes no§§
Indicated for colorectal cancer detection6,7 yes yes no no yes
Indicated for detection of precancer6-9 yes yes no no no#

Any noninvasive test with a positive result will need a follow-up colonoscopy.

FOBT requires changes to diet or medication10

Indicated for the detection of fecal occult blood11

§§Mobile phlebotomy may be available to collect a blood-based test sample at home with assistance from a medical professional12

#Current FDA-approved CRC blood test does not detect 87% of precancerous lesions9

THE STORY BEHIND THE TEST

Backed by science, powered by technology13,14

Cologuard Plus helps find colon cancer in its early stages, when it is more treatable.

A microcospic image of cells.

Gathering cells to uncover your body’s natural clues

  • Polyps are small, usually harmless growths in the colon
  • Left undetected, they can develop into cancer over time
  • These polyps can shed cells or leave behind microscopic amounts of blood in the stool that become clues to detecting cancer
Illustration of a DNA strand.

Advanced technology for targeted analysis

  • Using exclusive technology, your stool sample goes through a purification process in our lab
  • Cologuard Plus uses a precise biomarker panel to detect 4 distinct DNA markers (signs of DNA damage) and tiny blood traces, focusing on key mutations linked to colon cancer
  • This multi-marker approach can detect cancer early, even before symptoms appear or become serious
Illustration of a biomarker test panel with a syringe releasing a blood specimen.

Clear and actionable results within 8 to 10 days

  • Abnormal DNA or blood findings are weighted for a more accurate prediction of your risk for colon cancer
  • A positive result may mean a higher-than-average risk of precancerous polyps or colon cancer, while a negative result suggests a lower-than-average risk

AN FDA-APPROVED CHOICE

Trusted by over 340,000 providers.15 Chosen by 20 million patients.16

Easy to use
Fast shipping

“Five days later there’s this box at my door. It’s so easy...I just want people to get screened”

Meghan
Easy returns

“The Cologuard test took the pressure off of screening for colon cancer and was a total blessing for me.”

Yla

HOW TO GET THE COLOGUARD PLUS TEST

Two easy ways, one smart choice

A couple doing research using a laptop in a home setting.

Request online

Answer a few questions, and one of our telehealth providers can prescribe Cologuard Plus for you.

A doctor in consultation with a patient in a hospital setting.

Talk with your provider

Your health care provider can prescribe Cologuard Plus at any time. Our discussion guide makes starting those conversations easy.

If you’ve discussed Cologuard Plus with your health care provider in the past and believe it may have been ordered for you, please call Exact Sciences Laboratories at 1-844-870-8870.

Telehealth may be offered by your health care provider.

Telehealth providers may charge a fee for their services associated with the consultation. Telehealth providers operate independently from Exact Sciences and Exact Sciences Laboratories. Only orders from licensed health care providers are accepted.

You’ve got questions,
we’ve got answers


Cologuard is an FDA-approved, noninvasive, prescription-based, use-at-home collection kit for screening people 45 or older who are at average risk for colon cancer. Use it in the privacy of your home and ship it back to our lab for testing.

Cologuard Plus is for adults 45 years of age and older who are at average risk for colon cancer. It is not a replacement for colonoscopy in high-risk individuals.

Cologuard Plus uses advanced stool technology to detect DNA and blood cells released from altered cells. It can detect both colon cancer and precancer.

In a study that included a subset of nearly 19,000 average-risk patients aged 45-86, Cologuard Plus detected 95% of Stage I to IV colon cancers. In a subset of 20 adults aged 45-59, Cologuard Plus detected 100% of all colon cancers.1

If you’re 45+ and at average risk for colon cancer, there are two easy ways to request Cologuard Plus: online or through your health care provider. Either way, we’ll deliver your prescribed kit right to your door.

Cologuard Plus is the next-generation, FDA-approved version of Cologuard, designed to detect both colon cancer and precancer. Based on a subset of 18,911 average-risk patients aged 45-86 years from a prospective, multicenter study, the Cologuard Plus test offers1:


  • Accurate detection: Finds 95% of colon cancers
  • Finds precancers: Detects 43% of advanced precancerous growths and 74% of high-risk lesions
  • Peace of mind: A negative result means there's a 99.98% chance you don’t have colon cancer

The Cologuard Plus test detects blood and the DNA cells released from altered cells. It can detect both colon cancer and precancer.

Yes the Cologuard Plus test is FDA-approved to detect colon cancer and precancer.

Your kit comes with easy-to-follow, step-by-step sample-collection instructions. You can also download our Patient Guide or watch our how-to videos.

One of the most common myths and misconceptions is that you only need a screening if you’re experiencing symptoms like pain or bleeding. In reality, early-stage colon cancer is often a silent disease with no warning signs at all.1


The goal of screening is to find precancerous polyps before they turn into something serious, or to catch cancer when it’s small and highly treatable. Waiting for symptoms often means the disease has already progressed.

In a study that included nearly 19,000 average-risk patients aged 45-86, Cologuard Plus detected 95% of Stage I to IV colon cancers. In a subset of 20 adults aged 45-59, Cologuard Plus detected 100% of all colon cancers.1

The Cologuard Plus test is included on a wide range of insurance plans for eligible patients. Coverage can vary, check your insurance and which test is covered today.


To check if it’s available under your plan, use our insurance lookup tool.